Running title: Alkyl gallates induce division arrest in Xanthomonas citri
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چکیده
Faculdade de Ciências Farmacêuticas (FCF), Depto. de Ciências Biológicas, 6 Universidade Estadual Paulista (UNESP), Rod. Araraquara/Jau, Km 1, Araraquara, 7 SP, Brazil, 14801-902; Depto. de Química Orgânica, Instituto de Química, UNESP, 8 Av. Prof. Francisco Degni, s/n, Araraquara, SP, Brazil, 14800-900; Depto. Científico, 9 Fundecitrus , Av. Dr. Adhemar Pereira de Barros, 201, Araraquara, SP, Brazil, 1480710 040; Depto. de Princípios Ativos Naturais e Toxicologia, FCF, UNESP, Rod. 11 Araraquara/Jau, Km 1, Araraquara, SP, Brazil, 14801-902 12
منابع مشابه
Antibacterial activity of alkyl gallates is a combination of direct targeting of FtsZ and permeabilization of bacterial membranes
Alkyl gallates are compounds with reported antibacterial activity. One of the modes of action is binding of the alkyl gallates to the bacterial membrane and interference with membrane integrity. However, alkyl gallates also cause cell elongation and disruption of cell division in the important plant pathogen Xanthomonas citri subsp. citri, suggesting that cell division proteins may be targeted ...
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The plant-pathogenic bacterium Xanthomonas citri subsp. citri is the causal agent of Asiatic citrus canker, a serious disease that affects all the cultivars of citrus in subtropical citrus-producing areas worldwide. There is no curative treatment for citrus canker; thus, the eradication of infected plants constitutes the only effective control of the spread of X. citri subsp. citri. Since the e...
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Xanthomonas citri subsp citri (Xcc) is responsible for one of the most destructive diseases of citrus fruits, Asiatic citrus canker. Based on the bacterial host range, the pathogenic forms, A, A*, and Aw have been identified. A*-type strains are not well characterized and they have been reported to differ from other A-type strains on the basis of biochemical and genetic characteristics. In this...
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Alkyl gallates are anticipated for their use as anti-bacterial and anti-viral agents. Although their pharmacological activities depend on their alkyl chain length, no mechanism has yet been clarified. As described herein, we investigated the membrane binding properties of a series of alkyl gallates using fluorescence measurement to elucidate their different pharmacological activities. Membrane ...
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Xanthomonas citri (Xac) is the causal agent of citrus canker, a disease that affects citrus crops and causes economic impact worldwide. To further characterize cell division in this plant pathogen, we investigated the role of the protein MinC in cell division, chromosome segregation, and peptidoglycan incorporation by deleting the gene minC using allele exchange. Xac with minC deleted exhibited...
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